Induction of human plasmablasts during infection with antibiotic-resistant nosocomial bacteria.

نویسندگان

  • Victor I Band
  • Chris Ibegbu
  • Surinder Pal Kaur
  • Stephanie M Cagle
  • Ronald Trible
  • Crystal L Jones
  • Yun F Wang
  • Colleen S Kraft
  • Susan M Ray
  • Jens Wrammert
  • David S Weiss
چکیده

OBJECTIVES Nosocomial pathogens such as Acinetobacter baumannii are a growing public health threat, due in part to their increasing resistance to antibiotics. Since some strains are resistant to all available antibiotics, novel therapies are urgently needed. Plasmablasts are short-lived B cells found in the blood that can be collected and harnessed to produce therapeutic antibodies. We set out to determine whether plasmablasts are induced during infection with A. baumannii and other nosocomial pathogens. METHODS We obtained blood samples from patients infected with antibiotic-resistant nosocomial pathogens, and analysed their plasmablast response by flow cytometry. RESULTS We observed a strong induction of plasmablasts in patients with antibiotic-resistant A. baumannii infection. Furthermore, plasmablasts were also induced in response to other drug-resistant nosocomial pathogens. CONCLUSIONS These data suggest that plasmablasts may be broadly harnessed to develop therapeutic antibodies to combat otherwise untreatable antibiotic-resistant infections.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

شیوع بتالاکتامازهای وسیع الطیف در سویه های اشرشیاکلی و کلبسیلا پنومونیه ایزوله از بیماران بستری و سرپایی مبتلا به عفونت های ادراری در مراکز منتخب شهر اصفهان

  Background: Urinary Tract Infection (UTI) is the second most common infection in human. Most of UTIs are due to Escherichia coli ( E.coli) and Klebsiella pneumoniae ( K.pneumoniae) . These bacteria are relevant opportunistic pathogens that account for nosocomial infections. Prevalence of Extended-Spectrum Beta-lactamase (ESBLs) in pathogenic bacteria leads to antibiotic resistance and mortali...

متن کامل

Pattern of antibiotic resistance in nosocomial infections with Gram-negative bacilli in ICU patients (Tehran, Iran) during the years 2012-2014

Background and Objective: Owing to the new patterns of antibiotic resistance, selection of the appropriate antibiotics for the treatment of nosocomial infections, especially gram-negative bacilli, has become a big challenge. Therefore, the aim of this study was to evaluate the antibiotic resistance of nosocomial infections with Gram-negative bacilli in Iran during the years 2012-2014. Material...

متن کامل

Molecular Identification of Pathogenic Enterococci and Evaluation of Multi-drug Resistance in Enterococcus Species Isolated From Clinical samples of Some Hospitals in Tehran, Iran

Background: Multidrug-resistant (MDR) enterococci cause many problems for physicians and infection control specialists in the recent years. Hence, by the identification of antibiotic resistance patterns of enterococci in different geographical regions an appropriate strategy can be developed to prevent bacterial antibiotic resistance and provide effective treatment. The current study aimed at i...

متن کامل

Low incidence of multidrug-resistant bacteria and nosocomial infection due to a preventive multimodal nosocomial infection control: a 10-year single centre prospective cohort study in neurocritical care

BACKGROUND Nosocomial infection (NI) control is an important issue in neurocritical care due to secondary brain damage and the increased morbidity and mortality of primary acute neurocritical care patients. The primary aim of this study was to determine incidence of nosocomial infections and multidrug-resistant bacteria and seek predictors of nosocomial infections in a preventive multimodal nos...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of antimicrobial chemotherapy

دوره 69 7  شماره 

صفحات  -

تاریخ انتشار 2014